WP9. Immuno-monitoring, immune profiling
Sample/Species Objective Method/ Technique PBMC, Splenocytes Assessment of T cell responses ELISpot, ICS Serum [...]
WP 8. Pre-clinical non-animal models - In-vitro / OOC
System Type Objective Lymphoid OOC Non-animal Compare immune responses to different influenza vaccination platforms Human alveolar chip [...]
WP 7. Pre-Clinical Animal models - In vivo
Species Starin/ Model Objective Mouse Aged & Young Evaluate heterologous prime-boost vaccination (WNV, CHIKV, Mpox) Multivalent MVA-IAV vaccine studies Ferret - Multivalent MVA-IAV vaccine studies Mouse CC-Mice Up-dated multi-antigen MeV-based Flu vaccine studies [...]
Pre-clinical Studies
Pillar objectives Pillar 2 is dedicated to pre-clinical assessment of vaccine and antibody prototypes, including animal models (WP7), non-animal models (WP8) and immunomonitoring and immune profiling (WP9). Through a concerted effort by EVH partners, Pillar 2 aims to conceive and elaborate robust standardised protocols for pre-clinical analyses of vaccine and antibody candidates. WP7 Pre-clinical anima [...]
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