Pillar 2

WP 7. Pre-Clinical Animal models - In vivo

Species Starin/ Model Objective

Mouse

Aged & Young

Evaluate heterologous prime-boost vaccination (WNV, CHIKV, Mpox) Multivalent MVA-IAV vaccine studies

Ferret

-

Multivalent MVA-IAV vaccine studies

Mouse

CC-Mice

Up-dated multi-antigen MeV-based Flu vaccine studies

Mouse

IFNAR-/-

Up-dated multi-antigen MeV-based Flu vaccine studies

Hamster

Syrian

Flu vaccine comparison (classical vs. enhanced, with pre-immunity)

Mouse

Balb/c

Test immunogenicity of candidates and adjuvants

Mouse

CC, SLS

Identify susceptible strains, analyze immune response

NHP

-

Aerosol exposure studies, immunogenicity against HPAI H5N1

Hamster

Syrian golden

Assess vaccines/therapies against IAV, WNV or CHIKV)

Hamster

Syrian

Next Gen WNV vaccine analysis

Mouse

CAST/EiJ

Monkeypox virus studies

Mouse

k18-hDDP4

MERS-CoV studies